Protein Name:
Lysosomal proton-coupled steroid conjugate and bile acid symporter SLC46A3
|
UniprotKB/SwissProt ID: Q7Z3Q1 (Q7Z3Q1)
Gene Name:
SLC46A3
Organism: Homo sapiens (Human)
Function: Lysosomal proton-coupled steroid conjugate and bile acid transporter. Preferentially recognizes lipophilic steroid conjugates or bile acis as endogenous substrates and seems to mediate escape from lysosomes to the cytoplasm (PubMed:36741448). Modulates hepatic cytosolic copper homeostasis, maybe acting as a lysosomal copper transporter and sequestering copper ions in the lysosome (By similarity). Transports catabolites of non-cleavable antibody-drug conjugates from the lysosome to the cytoplasm (PubMed:26631267, PubMed:30131388, PubMed:36741448). Delivers pathogen-associated molecular patterns to cytosolic pattern recognition receptors as part of the innate immune response to microbes. Selectively transports bacterial muramyl dipeptide (MDP) into the cytosol for recognition by NOD2, triggering inflammatory responses (By similarity). Likely acts as a redundant importer of cyclic GMP-AMP dinucleotides (cGAMPs) in monocyte and macrophage cell lineages (PubMed:34235268). The transport mechanism, its electrogenicity and stoichiometry remain to be elucidated (Probable)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Lysosome membrane
|
|
|
Graphical Visualization of S-nitrosylation Sites:
|
|
The S-nitrosylation sites of Q7Z3Q1
|
| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
434 |
GLLLLPAISL C VVKCTSWNEG |
|
|
|
|
