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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Elongation factor-like GTPase 1

UniprotKB/SwissProt ID: Q7Z2Z2 (Q7Z2Z2)

Gene Name: EFL1

Organism: Homo sapiens (Human)

Function: GTPase involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with SBDS, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR041095 EFG_II
IPR035647 EFG_III/V
IPR000640 EFG_V-like
IPR056752 EFL1
IPR027417 P-loop_NTPase
IPR020568 Ribosomal_Su5_D2-typ_SF
IPR014721 Ribsml_uS5_D2-typ_fold_subgr
IPR005225 Small_GTP-bd
IPR000795 T_Tr_GTP-bd_dom
IPR009000 Transl_B-barrel_sf

The S-nitrosylation sites of Q7Z2Z2

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 124 IIVVDAVEGV C PQTQAVLRQA   
2 474 PTQDGSAIET C PKGEEPRGDE   
3 934 GNENQELQDG C SEAFEKRTSQ