Protein Name:
Zinc finger CCCH-type antiviral protein 1
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UniprotKB/SwissProt ID: Q7Z2W4 (Q7Z2W4)
Gene Name:
ZC3HAV1
Organism: Homo sapiens (Human)
Function: Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of RIGI signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Nucleus. Cytoplasm
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q7Z2W4
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
15 |
EVCCFITKIL C AHGGRMALDA |
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| 2 |
150 |
QSDPFFMPEI C KSYKGEGRQQ |
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| 3 |
168 |
RQQICNQQPP C SRLHICDHFT |
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| 4 |
187 |
FTRGNCRFPN C LRSHNLMDRK |
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| 5 |
219 |
PDVVQNIQDI C NSKHMQKNPP |
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| 6 |
272 |
ASASASAERS C TPSPDQISHR |
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| 7 |
581 |
SYTINFRVMS C DSFPIRRLST |
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| 8 |
645 |
SSYLESLYQS C PRGVVPFQAG |
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| 9 |
721 |
TATFRPQEDF C FLSSKKYKLS |
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| 10 |
831 |
AKDAIYSHKN C PYDAKNVVMF |
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| 11 |
867 |
YTSPPPQFDS C VDTRSNPSVF |
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| 12 |
96 |
HLCKLNLLGR C NYSQSERNLC |
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