Protein Name:
tRNA (guanine(27)-N(2))-dimethyltransferase
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UniprotKB/SwissProt ID: Q7Z2T5 (Q7Z2T5)
Gene Name:
TRMT1L
Organism: Homo sapiens (Human)
Function: Specifically dimethylates a single guanine residue at position 27 of tRNA(Tyr) using S-adenosyl-L-methionine as donor of the methyl groups (PubMed:39786990, PubMed:39786998). Dimethylation at position 27 of tRNA(Tyr) is required for efficient translation of tyrosine codons (PubMed:39786990, PubMed:39786998). Also required to maintain 3-(3-amino-3-carboxypropyl)uridine (acp3U) in the D-loop of several cytoplasmic tRNAs (PubMed:39786990, PubMed:39786998)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus, nucleolus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q7Z2T5
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
239 |
LKEADTDVQV C PNYSIPQKTD |
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| 2 |
320 |
ENSVTLIQEN C HLNKLKVVVD |
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| 3 |
656 |
MNMPKLKKFL C YLSQAGFRVS |
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