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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Alpha-actinin-1

UniprotKB/SwissProt ID: Q7TPR4 (Q7TPR4)

Gene Name: Actn1

Organism: Mus musculus (Mouse)

Function: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line. Cell membrane. Cell junction. Cell projection, ruffle

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR001589 Actinin_actin-bd_CS
IPR001715 CH_dom
IPR036872 CH_dom_sf
IPR011992 EF-hand-dom_pair
IPR014837 EF-hand_Ca_insen
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR018159 Spectrin/alpha-actinin
IPR002017 Spectrin_repeat

The S-nitrosylation sites of Q7TPR4

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 154 TSAKEGLLLW C QRKTAPYKNV  CCCCCCCCCC C CCCCHHHCCH  2.57%
2 180 HISWKDGLGF C ALIHRHRPEL  CCCCCCCCCC C CCCCHHHCCH  2.6%
3 332 LHKPPKVQEK C QLEINFNTLQ  CCCCCCCCCC C CCCCHHHCCH  5.7% 20925432
4 41 KQQRKTFTAW C NSHLRKAGTQ  CCCCCCCCCC C CCCCHHHCCH  3.29%
5 476 YYDSPSVNAR C QKICDQWDNL  CCCCCCCCCC C CCCCHHHCCH  4.49%
6 480 PSVNARCQKI C DQWDNLGALT  CCCCCCCCCC C CCCCHHHCCH  4.02%
7 774 GTLGPEEFKA C LISLGYDIGN  CCCCCCCCCC C CCCCHHHCCH  3.41%