Protein Name:
Heterogeneous nuclear ribonucleoprotein Q
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UniprotKB/SwissProt ID: Q7TMK9 (Q7TMK9)
Gene Name:
Syncrip
Organism: Mus musculus (Mouse)
Function: Heterogeneous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD-mediated complex that promotes MYC mRNA stability. Isoform 1 and isoform 2 are associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences (By similarity). Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself (By similarity). May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (By similarity). Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. Isoform 2 may be involved in cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Nucleus, nucleoplasm. Microsome. Cytoplasm
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q7TMK9
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
211 |
LNRGYAFVTF C TKEAAQEAVK |
CCCCCCCCCC C CCCCCCCEEE |
3.77% |
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| 2 |
289 |
PDDKKKNRGF C FLEYEDHKTA |
CCCCCCCCCC C CCCCCCCEEE |
4.19% |
20925432
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| 3 |
96 |
SHVQNKSAFL C GVMKTYRQRE |
CCCCCCCCCC C CCCCCCCEEE |
2.89% |
19101475
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