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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Protein MCM10 homolog

UniprotKB/SwissProt ID: Q7L590 (Q7L590)

Gene Name: MCM10

Organism: Homo sapiens (Human)

Function: Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication. Key effector of the RBBP6 and ZBTB38-mediated regulation of DNA-replication and common fragile sites stability; acts as a direct target of transcriptional repression by ZBTB38 (PubMed:24726359)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR040184 Mcm10
IPR055065 MCM10_OB
IPR012340 NA-bd_OB-fold
IPR015411 Rep_factor_Mcm10_C
IPR015408 Znf_Mcm10/DnaG
IPR056791 Znf_Mcm10_C

The S-nitrosylation sites of Q7L590

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 515 KLGIPQKSLS C SEEFKELMDL