Protein Name:
Cytoplasmic FMR1-interacting protein 1
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UniprotKB/SwissProt ID: Q7L576 (Q7L576)
Gene Name:
CYFIP1
Organism: Homo sapiens (Human)
Function: Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). May act as an invasion suppressor in cancers
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Cytoplasm, perinuclear region. Cell projection, lamellipodium. Cell projection, ruffle. Synapse, synaptosome
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q7L576
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
1241 |
GEGTPVEHVR C FQPPIHQSLA |
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| 2 |
334 |
HYEENKSRWT C TSSGSSPQYN |
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| 3 |
428 |
HPTDKYSNKD C PDSAEEYERA |
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| 4 |
98 |
SCSRAIPQVK C NEQPNRVEIY |
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37478858
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| 5 |
993 |
IVEYAELKTV C FQNLREVGNA |
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