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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: ATP-dependent RNA helicase DHX30

UniprotKB/SwissProt ID: Q7L2E3 (Q7L2E3)

Gene Name: DHX30

Organism: Homo sapiens (Human)

Function: RNA-dependent helicase (PubMed:29100085). Plays an important role in the assembly of the mitochondrial large ribosomal subunit (PubMed:25683715, PubMed:29100085). Required for optimal function of the zinc-finger antiviral protein ZC3HAV1 (By similarity). Associates with mitochondrial DNA (PubMed:18063578). Involved in nervous system development and differentiation through its involvement in the up-regulation of a number of genes which are required for neurogenesis, including GSC, NCAM1, neurogenin, and NEUROD (By similarity)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Mitochondrion. Mitochondrion matrix, mitochondrion nucleoid

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR011709 DEAD-box_helicase_OB_fold
IPR011545 DEAD/DEAH_box_helicase_dom
IPR002464 DNA/RNA_helicase_DEAH_CS
IPR056755 DSRM_2
IPR007502 Helicase-assoc_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C-like
IPR027417 P-loop_NTPase

The S-nitrosylation sites of Q7L2E3

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 1005 PSDCTLASAQ C NEYSEEEELV   
2 1183 ALLAELLRGP C GSFDVRKTAD   
3 286 KLSTLTLLWP C PMTFVAKGRR   
4 309 EAENKAAALA C KKLKSLGLVD   
5 346 RELGETQRRP C TIQVPEPILR   
6 461 PVVVISGDTG C GKTTRIPQLL   
7 606 NERFSRYFGG C PVIKVPGFMY   
8 673 DARGEPGGIL C FLPGWQEIKG   
9 765 ERYDLKTKVS C LETVWVSRAN   
10 786 VIQRRGRAGR C QSGFAYHLFP    37478858