UniprotKB/SwissProt ID: Q7L0Q8 (Q7L0Q8)
Gene Name:
RHOU
Organism: Homo sapiens (Human)
Function: Binds to and activates protein kinase PAK1 (PubMed:11459829). Plays a role in the regulation of cell morphology, cytoskeletal organization and focal adhesion assembly during cell migration (PubMed:11459829, PubMed:17620058, PubMed:18086875, PubMed:21834987). Also stimulates quiescent cells to reenter the cell cycle (PubMed:11459829). Has no detectable GTPase activity but its high intrinsic guanine nucleotide exchange activity suggests it is constitutively GTP-bound (PubMed:16472646)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Golgi apparatus membrane. Cell junction, focal adhesion. Cell projection, podosome
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