Protein Name:
Probable ATP-dependent RNA helicase DDX46
|
UniprotKB/SwissProt ID: Q7L014 (Q7L014)
Gene Name:
DDX46
Organism: Homo sapiens (Human)
Function: Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:32494006, PubMed:34822310, PubMed:36797247). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, DDX46 plays essential roles during assembly of pre-spliceosome and proofreading of the branch site (PubMed:34822310)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus speckle. Nucleus, Cajal body
|
|
|
Graphical Visualization of S-nitrosylation Sites:
|
|
The S-nitrosylation sites of Q7L014
|
| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
377 |
CPKPIKSWVQ C GISMKILNSL |
|
|
|
| 2 |
478 |
FSKTLGLRVV C VYGGTGISEQ |
|
|
|
| 3 |
501 |
ELKRGAEIIV C TPGRMIDMLA |
|
|
|
| 4 |
590 |
EVQVGGRSVV C SDVEQQVIVI |
|
|
|
| 5 |
646 |
LKDLMRASYP C MSLHGGIDQY |
|
|
|
| 6 |
696 |
KHLILVVNYS C PNHYEDYVHR |
|
|
|
|
