Protein Name:
Staphylococcal nuclease domain-containing protein 1
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UniprotKB/SwissProt ID: Q7KZF4 (Q7KZF4)
Gene Name:
SND1
Organism: Homo sapiens (Human)
Function: Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs (PubMed:18453631, PubMed:28546213). As part of its function in miRNA decay, regulates mRNAs involved in G1-to-S phase transition (PubMed:28546213). Functions as a bridging factor between STAT6 and the basal transcription factor (PubMed:12234934). Plays a role in PIM1 regulation of MYB activity (PubMed:9809063). Functions as a transcriptional coactivator for STAT5 (By similarity) (Microbial infection) Functions as a transcriptional coactivator for the Epstein-Barr virus nuclear antigen 2 (EBNA2) (Microbial infection) Promotes SARS-CoV-2 RNA synthesis by binding to negative-sense RNA and the viral protein nsp9
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Nucleus. Melanosome
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q7KZF4
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
152 |
NNPEQNRLSE C EEQAKAAKKG |
CCCCCCCCCC C CCCCCCHHHH |
6.65% |
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| 2 |
228 |
LVTVMLSGIK C PTFRREADGS |
CCCCCCCCCC C CCCCCCHHHH |
3.47% |
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| 3 |
296 |
ELLLKEGFAR C VDWSIAVYTR |
CCCCCCCCCC C CCCCCCHHHH |
2.67% |
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| 4 |
31 |
RGIIKMVLSG C AIIVRGQPRG |
CCCCCCCCCC C CCCCCCHHHH |
1.9% |
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| 5 |
440 |
ETVPAFSERT C ATVTIGGINI |
CCCCCCCCCC C CCCCCCHHHH |
3.61% |
19483679
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| 6 |
549 |
RLKLYLPKET C LITFLLAGIE |
CCCCCCCCCC C CCCCCCHHHH |
2.44% |
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| 7 |
560 |
LITFLLAGIE C PRGARNLPGL |
CCCCCCCCCC C CCCCCCHHHH |
2.35% |
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| 8 |
736 |
GSYAPRRGEF C IAKFVDGEWY |
CCCCCCCCCC C CCCCCCHHHH |
2.29% |
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| 9 |
96 |
LRKKLIGKEV C FTIENKTPQG |
CCCCCCCCCC C CCCCCCHHHH |
2.33% |
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