UniprotKB/SwissProt ID: Q7K738 (Q7K738)
Gene Name:
Ubc10
Organism: Drosophila melanogaster (Fruit fly)
Function: Ubiquitin-conjugating enzyme E2 that acts with the RBR family ligases LUBEL, ari-1 and possibly parkin (PubMed:21900267, PubMed:27702987, PubMed:29689197). Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (By similarity). Appears to be involved in the selective degradation of short-lived and abnormal proteins (PubMed:21900267, PubMed:27702987, PubMed:29689197). Functions with ari-1 to control the subcellular localization and morphology of muscle nuclei (myonuclei) by regulating the protein levels and distribution of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex (PubMed:29689197). Functions by mediating the monoubiquitination of the LINC complex subunit koi leading to its subsequent proteasomal degradation (PubMed:29689197). Likely to function with ari-1 to control metamorphosis by regulating the proteins levels of EcR isoform A (ECR-A) and it's heterodimeric partner usp, via the ubiquitination and subsequent degradation of ECR-A (PubMed:21900267). Able to function with LUBEL to mediate 'Lys-63'- and linear 'Met-1'-linked polyubiquitin involved in the heat stress response (PubMed:27702987)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization:
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