Protein Name:
Mitochondrial carrier homolog 2
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UniprotKB/SwissProt ID: Q791V5 (Q791V5)
Gene Name:
Mtch2
Organism: Mus musculus (Mouse)
Function: Protein insertase that mediates insertion of transmembrane proteins into the mitochondrial outer membrane. Catalyzes insertion of proteins with alpha-helical transmembrane regions, such as signal-anchored, tail-anchored and multi-pass membrane proteins. Does not mediate insertion of beta-barrel transmembrane proteins (By similarity). Also acts as a receptor for the truncated form of pro-apoptotic BH3-interacting domain death agonist (p15 BID) and has therefore a critical function in apoptosis (PubMed:20436477, PubMed:26219591, PubMed:26876167, PubMed:30510213). Regulates the quiescence/cycling of hematopoietic stem cells (HSCs) (PubMed:20436477, PubMed:26219591, PubMed:26876167). Acts as a regulator of mitochondrial fusion, essential for the naive-to-primed interconversion of embryonic stem cells (ESCs) (PubMed:30510213). Acts as a regulator of lipid homeostasis and has a regulatory role in adipocyte differentiation and biology (PubMed:26876167, PubMed:28127879)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion outer membrane
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Graphical Visualization of S-nitrosylation Sites:
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| InterPro ID |
Domain Name |
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IPR018108
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Mitochondrial_sb/sol_carrier |
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IPR023395
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Mt_carrier_dom_sf |
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The S-nitrosylation sites of Q791V5
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
296 |
FRKVPCGKTY C YDLRMLI--- |
CCHHHHHHHH C CCCCHHCCCC |
2.29% |
21278135
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| 2 |
49 |
IGRNIFGRQV C QLPGLFCYAQ |
CCHHHHHHHH C CCCCHHCCCC |
2.32% |
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| 3 |
56 |
RQVCQLPGLF C YAQHIASIDG |
CCHHHHHHHH C CCCCHHCCCC |
3.11% |
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| 4 |
79 |
GLFTGLTPRL C SGVLGTVVHG |
CCHHHHHHHH C CCCCHHCCCC |
3.34% |
21278135
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