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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Staphylococcal nuclease domain-containing protein 1

UniprotKB/SwissProt ID: Q78PY7 (Q78PY7)

Gene Name: Snd1

Organism: Mus musculus (Mouse)

Function: Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs (By similarity). As part of its function in miRNA decay, regulates mRNAs involved in G1-to-S phase transition (By similarity). Functions as a bridging factor between STAT6 and the basal transcription factor (By similarity). Plays a role in PIM1 regulation of MYB activity (By similarity). Functions as a transcriptional coactivator for STAT5 (PubMed:12819296)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Nucleus. Melanosome

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR016685 Silence_cplx_Nase-comp_TudorSN
IPR035437 SNase_OB-fold_sf
IPR016071 Staphylococal_nuclease_OB-fold
IPR002071 Thermonucl_AS
IPR002999 Tudor
IPR047386 Tudor_TDRD11

The S-nitrosylation sites of Q78PY7

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 152 NNPEQNRLSE C EEQAKASKKG  CCCCCCCCCC C CCCCCCCHHH  6.65% 20925432
2 228 LVTVMLSGIK C PTFRRETDGS  CCCCCCCCCC C CCCCCCCHHH  3.47% 20925432
3 31 RGIVKMVLSG C AIIVRGQPRG  CCCCCCCCCC C CCCCCCCHHH  1.9% 22178444
4 440 ETVPAFSERT C ATVTIGGINI  CCCCCCCCCC C CCCCCCCHHH  3.61% 20925432
5 826 SVVRDIQNTQ C LLNVEHLSAS  CCCCCCCCCC C CCCCCCCHHH  4.37%
6 96 LRKKLIGKEV C FTIENKTPQG  CCCCCCCCCC C CCCCCCCHHH  2.33% 22178444
20925432