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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Eukaryotic translation initiation factor 4G

UniprotKB/SwissProt ID: Q76E23 (Q76E23)

Gene Name: EIF4G

Organism: Arabidopsis thaliana (Mouse-ear cress)

Function: Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. Plays a role in the accumulation of some potyvirus during viral infection. Required for the accumulation of cucumber mosaic virus 3a protein and turnip crinkle virus p28 replication protein during viral infection. These proteins are necessary for cell-to-cell movement of the virus

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR016024 ARM-type_fold
IPR003891 Initiation_fac_eIF4g_MI
IPR003890 MIF4G-like_typ-3

The S-nitrosylation sites of Q76E23

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 1246 RMLTEKIMHA C IQKLLGYNQD   
2 1297 GYFEKMKMLS C KQELSSRVRF   
3 1563 SARDENEIGM C MKDMNSPAYH   
4 553 ISLSQKNVEA C SLSSSQQPKP   
5 628 SESISVEDQT C KVEPPHNLTE   
6 720 GSSPQEKDLK C DNRTASDKLD