Protein Name:
Kynurenine--oxoglutarate transaminase 3
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UniprotKB/SwissProt ID: Q71RI9 (Q71RI9)
Gene Name:
Kyat3
Organism: Mus musculus (Mouse)
Function: Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA), an intermediate in the tryptophan catabolic pathway which is also a broad spectrum antagonist of the three ionotropic excitatory amino acid receptors among others (PubMed:19029248). May catalyze the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond (PubMed:19029248). Has transaminase activity towards L-kynurenine, tryptophan, phenylalanine, serine, cysteine, methionine, histidine, glutamine and asparagine with glyoxylate as an amino group acceptor (in vitro). Has lower activity with 2-oxoglutarate as amino group acceptor (in vitro) (PubMed:19029248)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization:
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q71RI9
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
113 |
GHPALVKALS C LYGKIYQRQI |
CCHHHHHHHH C CCCCCCCEEE |
3.36% |
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| 2 |
338 |
IDIKRMDDPE C YFNSLPKELE |
CCHHHHHHHH C CCCCCCCEEE |
5.98% |
21278135
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| 3 |
417 |
KLTAIPVSAF C DSKSKPHFEK |
CCHHHHHHHH C CCCCCCCEEE |
6.05% |
21278135
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| 4 |
432 |
KPHFEKLVRF C FIKKDSTLDA |
CCHHHHHHHH C CCCCCCCEEE |
2.12% |
21278135
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