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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Netrin receptor UNC5A

UniprotKB/SwissProt ID: Q6ZN44 (Q6ZN44)

Gene Name: UNC5A

Organism: Homo sapiens (Human)

Function: Receptor for netrin required for axon guidance. Functions in the netrin signaling pathway and promotes neurite outgrowth in response to NTN1. Mediates axon repulsion of neuronal growth cones in the developing nervous system in response to netrin. Axon repulsion in growth cones may be mediated by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cell membrane. Membrane raft. Cell projection, neuron projection

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR011029 DEATH-like_dom_sf
IPR000488 Death_dom
IPR042155 Death_UNC5A
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
IPR037936 UNC5
IPR033772 UPA
IPR000906 ZU5_dom

The S-nitrosylation sites of Q6ZN44

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 603 LKLLLFAPVA C TSLEYNIRVY