Protein Name:
Tripartite motif-containing protein 72
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UniprotKB/SwissProt ID: Q6ZMU5 (Q6ZMU5)
Gene Name:
TRIM72
Organism: Homo sapiens (Human)
Function: Muscle-specific E3 ubiquitin-protein ligase that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites (PubMed:36944613). Its ubiquitination activity is mediated by E2 ubiquitin-conjugating enzymes UBE2D1, UBE2D2 and UBE2D3 (By similarity). Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site (By similarity). This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation (By similarity). Probably acts upstream of the Ca(2+)-dependent membrane resealing process (By similarity). Required for transport of DYSF to sites of cell injury during repair patch formation (By similarity). Regulates membrane budding and exocytosis (By similarity). May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane, sarcolemma. Cytoplasmic vesicle membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q6ZMU5
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
144 |
PQQKLQLQEA C MRKEKSVAVL |
CCCCCCHHHH H CCCHHHHHHC |
2.39% |
24487118
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