UniprotKB/SwissProt ID: Q6WQJ1 (Q6WQJ1)
Gene Name:
Dagla
Organism: Mus musculus (Mouse)
Function: Serine hydrolase that hydrolyzes arachidonic acid-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid (eCB), 2-arachidonoylglycerol (2-AG) (PubMed:17584991, PubMed:23103940). Preferentially hydrolyzes sn-1 fatty acids from diacylglycerols (DAG) that contain arachidonic acid (AA) esterified at the sn-2 position to biosynthesize 2-AG. Has negligible activity against other lipids including monoacylglycerols and phospholipids (PubMed:17584991). Plays a key role in regulating 2-AG signaling in the central nervous system (CNS) (PubMed:20147530, PubMed:20159446, PubMed:25466252, PubMed:26668358, PubMed:26779719). Controls the activity of 2-AG as a retrograde messenger at neuronal synapses (PubMed:20147530, PubMed:20159446, PubMed:26668358). Supports axonal growth during development and adult neurogenesis (PubMed:20147530). Plays a role for eCB signaling in the physiological regulation of anxiety and depressive behaviors (PubMed:25466252). Also regulates neuroinflammatory responses in the brain, in particular, LPS-induced microglial activation (PubMed:26779719)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Cell projection, dendritic spine membrane. Postsynaptic density membrane. Early endosome membrane
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