Protein Name:
Activating transcription factor 7-interacting protein 1
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UniprotKB/SwissProt ID: Q6VMQ6 (Q6VMQ6)
Gene Name:
ATF7IP
Organism: Homo sapiens (Human)
Function: Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Required for HUSH-mediated heterochromatin formation and gene silencing (PubMed:27732843). Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1 (PubMed:12665582). Stabilizes SETDB1, is required to stimulate histone methyltransferase activity of SETDB1 and facilitates the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) (PubMed:14536086, PubMed:27732843). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells (PubMed:19106100)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q6VMQ6
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
1256 |
KDIYGRFGPF C DPQSTDVISS |
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| 2 |
297 |
RTFEPKSVPV C EPVPEIDNIE |
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| 3 |
360 |
ETLETDDTTI C SDRPPENEKK |
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| 4 |
451 |
KLAPSEDELT C FSKTSLLPID |
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| 5 |
93 |
GSKAEWKETP C ILSVNVKNKQ |
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| 6 |
955 |
SKKAADSTSQ C GKATGSDSSG |
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