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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Monofunctional C1-tetrahydrofolate synthase, mitochondrial

UniprotKB/SwissProt ID: Q6UB35 (Q6UB35)

Gene Name: MTHFD1L

Organism: Homo sapiens (Human)

Function: May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism complementing thus the enzymatic activities of MTHFD2

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Mitochondrion

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR046346 Aminoacid_DH-like_N_sf
IPR000559 Formate_THF_ligase
IPR020628 Formate_THF_ligase_CS
IPR036291 NAD(P)-bd_dom_sf
IPR027417 P-loop_NTPase
IPR000672 THF_DH/CycHdrlase
IPR020630 THF_DH/CycHdrlase_cat_dom
IPR020631 THF_DH/CycHdrlase_NAD-bd_dom

The S-nitrosylation sites of Q6UB35

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 198 GKLVRGDAHE C FVSPVAKAVI   
2 302 SHDFLSGKVG C GSPRIHFGGL   
3 61 RPQDGQARSS C SPGGRTPAAR   
4 814 TDTRAEIDLV C ELAKRAGAFD   
5 828 KRAGAFDAVP C YHWSVGGKGS   
6 906 TQQGFGNLPI C MAKTHLSLSH