Protein Name:
Reticulon-3
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UniprotKB/SwissProt ID: Q6RJR6 (Q6RJR6)
Gene Name:
Rtn3
Organism: Rattus norvegicus (Rat)
Function: May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. Induces the formation of endoplasmic reticulum tubules. Acts also as an inflammation-resolving regulator by interacting with both TRIM25 and RIGI, subsequently impairing RIGI 'Lys-63'-linked polyubiquitination leading to IRF3 and NF-kappa-B inhibition
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Endoplasmic reticulum membrane. Golgi apparatus membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q6RJR6
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
47 |
ALGAKSCGSS C AVGLSSLCSD |
CCCCCCCCCC C CCCCCCCCCC |
3.68% |
22178444
16418269
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