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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: WD repeat-containing protein 74

UniprotKB/SwissProt ID: Q6RFH5 (Q6RFH5)

Gene Name: WDR74

Organism: Homo sapiens (Human)

Function: Regulatory protein of the MTREX-exosome complex involved in the synthesis of the 60S ribosomal subunit (PubMed:26456651). Participates in an early cleavage of the pre-rRNA processing pathway in cooperation with NVL (PubMed:29107693). Required for blastocyst formation, is necessary for RNA transcription, processing and/or stability during preimplantation development (By similarity)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus, nucleolus. Nucleus

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR036322 WD40_repeat_dom_sf
IPR001680 WD40_rpt
IPR037379 WDR74/Nsa1

The S-nitrosylation sites of Q6RFH5

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 201 FLPGSQKLVT C TGYHQVRVYD   
2 316 HKVYLKSQLN C LLLSGRDNWE