Protein Name:
Guanine nucleotide-binding protein subunit alpha-13
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UniprotKB/SwissProt ID: Q6Q7Y5 (Q6Q7Y5)
Gene Name:
Gna13
Organism: Rattus norvegicus (Rat)
Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:12176367). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF1/p115RhoGEF, ARHGEF11/PDZ-RhoGEF and ARHGEF12/LARG) (By similarity). GNA13-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway (By similarity). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (By similarity). In lymphoid follicles, transmits P2RY8- and S1PR2-dependent signals that lead to inhibition of germinal center (GC) B cell growth and migration outside the GC niche
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Membrane. Melanosome. Cytoplasm. Nucleus
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Graphical Visualization of S-nitrosylation Sites:
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