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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: ATPase family AAA domain-containing protein 2

UniprotKB/SwissProt ID: Q6PL18 (Q6PL18)

Gene Name: ATAD2

Organism: Homo sapiens (Human)

Function: May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR003593 AAA+_ATPase
IPR041569 AAA_lid_3
IPR045199 ATAD2-like
IPR003959 ATPase_AAA_core
IPR003960 ATPase_AAA_CS
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR027417 P-loop_NTPase

The S-nitrosylation sites of Q6PL18

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 1057 KDYLRDIDLI C SNALEYNPDR   
2 1246 KLELRNNSNT C NIENELEDSR   
3 785 FNFLHLNRNA C YQPMSFRPRI