Protein Name:
Zinc finger CCCH domain-containing protein 14
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UniprotKB/SwissProt ID: Q6PJT7 (Q6PJT7)
Gene Name:
ZC3H14
Organism: Homo sapiens (Human)
Function: RNA-binding protein involved in the biogenesis of circular RNAs (circRNAs), which are produced by back-splicing circularization of pre-mRNAs (PubMed:39461343). Acts by binding to both exon-intron boundary and 3'-UTR of pre-mRNAs to promote circRNA biogenesis through dimerization and the association with the spliceosome (PubMed:39461343). Required for spermatogenesis via involvement in circRNA biogenesis (PubMed:39461343). Regulates the pre-mRNA processing of ATP5MC1; preventing its degradation (PubMed:27563065). Also binds the poly(A) tail of mRNAs; controlling poly(A) length in neuronal cells (PubMed:17630287, PubMed:24671764)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus speckle. Nucleus speckle. Nucleus speckle. Cytoplasm
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q6PJT7
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
261 |
SSWVYETGRL C EPEVLNSLEE |
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| 2 |
607 |
LLERCKYWPA C KNGDECAYHH |
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| 3 |
693 |
RYFPACKKME C PFYHPKHCRF |
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