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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Sodium/potassium-transporting ATPase subunit alpha-2

UniprotKB/SwissProt ID: Q6PIE5 (Q6PIE5)

Gene Name: Atp1a2

Organism: Mus musculus (Mouse)

Function: This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (By similarity)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Membrane. Cell membrane

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR006068 ATPase_P-typ_cation-transptr_C
IPR004014 ATPase_P-typ_cation-transptr_N
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR050510 Cation_transp_ATPase_P-type
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR005775 P-type_ATPase_IIC
IPR001757 P_typ_ATPase
IPR044492 P_typ_ATPase_HD_dom

The S-nitrosylation sites of Q6PIE5

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 209 ADLRIISSHG C KVDNSSLTGE  CCCCCCCCCC C CCCCCCCCCC  3.04% 24895380
21278135
2 241 HENPLETRNI C FFSTNCVEGT  CCCCCCCCCC C CCCCCCCCCC  3% 24895380
22588120
3 247 TRNICFFSTN C VEGTARGIVI  CCCCCCCCCC C CCCCCCCCCC  2.74% 24895380
22588120
4 372 VETLGSTSTI C SDKTGTLTQN  CCCCCCCCCC C CCCCCCCCCC  4.33% 22588120
21278135
5 426 WTALSRIAGL C NRAVFKAGQE  CCCCCCCCCC C CCCCCCCCCC  2.95%
6 457 GDASESALLK C IELSCGSVRK  CCCCCCCCCC C CCCCCCCCCC  2.7% 24895380
7 462 SALLKCIELS C GSVRKMRDRN  CCCCCCCCCC C CCCCCCCCCC  8.02% 24895380
8 515 KGAPERILDR C STILVQGKEI  CCCCCCCCCC C CCCCCCCCCC  4.14% 24895380
9 553 GGLGERVLGF C QLNLPSGKFP  CCCCCCCCCC C CCCCCCCCCC  4.22% 24895380
22588120
10 603 RAAVPDAVGK C RSAGIKVIMV  CCCCCCCCCC C CCCCCCCCCC  3.23%
11 660 SQVNPREAKA C VVHGSDLKDM  CCCCCCCCCC C CCCCCCCCCC  3.02% 24895380
21278135
12 702 PQQKLIIVEG C QRQGAIVAVT  CCCCCCCCCC C CCCCCCCCCC  1.58% 24895380
22588120
21278135