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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Sodium/potassium-transporting ATPase subunit alpha-3
UniprotKB/SwissProt ID: Q6PIC6 (Q6PIC6)

Gene Name: Atp1a3

Organism: Mus musculus (Mouse)

Function: This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (By similarity)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cell membrane

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR006068 ATPase_P-typ_cation-transptr_C
IPR004014 ATPase_P-typ_cation-transptr_N
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR050510 Cation_transp_ATPase_P-type
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR005775 P-type_ATPase_IIC
IPR001757 P_typ_ATPase
IPR044492 P_typ_ATPase_HD_dom
The S-nitrosylation sites of Q6PIC6
No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 201 ADLRIISAHG C KVDNSSLTGE  CCCCCCCCCC C CHHHHHHHCC  2.52% 24895380
2 221 ESEPQTRSPD C THDNPLETRN  CCCCCCCCCC C CHHHHHHHCC  4.06% 24895380
3 239 TRNITFFSTN C VEGTARGVVV  CCCCCCCCCC C CHHHHHHHCC  2.74% 24895380
22588120
4 364 VETLGSTSTI C SDKTGTLTQN  CCCCCCCCCC C CHHHHHHHCC  4.33% 24895380
22588120
5 418 WVALSHIAGL C NRAVFKGGQD  CCCCCCCCCC C CHHHHHHHCC  2.95% 24895380
6 42 TEHKMSVEEV C RKYNTDCVQG  CCCCCCCCCC C CHHHHHHHCC  3.34%
7 449 GDASESALLK C IELSSGSVKL  CCCCCCCCCC C CHHHHHHHCC  2.7% 24895380
8 49 EEVCRKYNTD C VQGLTHSKAQ  CCCCCCCCCC C CHHHHHHHCC  2.01% 24895380
22588120
9 508 KGAPERILDR C ATILLQGKEQ  CCCCCCCCCC C CHHHHHHHCC  3.8% 24895380
10 546 GGLGERVLGF C HYYLPEEQFP  CCCCCCCCCC C CHHHHHHHCC  1.59% 22588120
11 596 RAAVPDAVGK C RSAGIKVIMV  CCCCCCCCCC C CHHHHHHHCC  3.23%
12 653 SQVNPRDAKA C VIHGTDLKDF  CCCCCCCCCC C CHHHHHHHCC  2.66% 24895380
13 695 PQQKLIIVEG C QRQGAIVAVT  CCCCCCCCCC C CHHHHHHHCC  1.58% 24895380
22588120