Protein Name:
2-aminoethanethiol dioxygenase
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UniprotKB/SwissProt ID: Q6PDY2 (Q6PDY2)
Gene Name:
Ado
Organism: Mus musculus (Mouse)
Function: Plays a vital role in regulating thiol metabolism and preserving oxygen homeostasis by oxidizing the sulfur of cysteamine and N-terminal cysteine-containing proteins to their corresponding sulfinic acids using O2 as a cosubstrate (PubMed:17581819, PubMed:32601061). Catalyzes the oxidation of cysteamine (2-aminoethanethiol) to hypotaurine (PubMed:17581819, PubMed:32601061). Catalyzes the oxidation of the regulator of G-protein signaling 5 (RGS5) (PubMed:32601061). Also oxidizes proteins RGS4 and interleukin-32 (IL32) (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization:
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q6PDY2
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
169 |
RAEYTEASGP C VLTPHRDNLH |
CCCCHHHHHH H HHHHHHHHHC |
4.46% |
20925432
21278135
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| 2 |
225 |
IRPKEASGSA C DLPREVWLLE |
CCCCHHHHHH H HHHHHHHHHC |
6.22% |
21278135
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