UniprotKB/SwissProt ID: Q6P9J9 (Q6P9J9)
Gene Name:
Ano6
Organism: Mus musculus (Mouse)
Function: Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets, osteoblasts and fetal thymocytes (PubMed:21107324, PubMed:21908539, PubMed:22936354, PubMed:23021219, PubMed:23532839, PubMed:30785399, PubMed:31015464, PubMed:39495104). Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization (PubMed:22936354, PubMed:23021219). Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (PubMed:23532839). Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes (PubMed:23021219)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane
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