UniprotKB/SwissProt ID: Q6P5S7 (Q6P5S7)
Gene Name:
RNASEK
Organism: Homo sapiens (Human)
Function: Endoribonuclease which preferentially cleaves ApU and ApG phosphodiester bonds. Hydrolyzes UpU bonds at a lower rate (PubMed:17881363). Regulates the activity of vacuolar (H+)-ATPase (V-ATPase) which is responsible for acidifying and maintaining the pH of intracellular compartments (PubMed:26212330). Required at an early stage of receptor-mediated endocytosis (PubMed:26212330) (Microbial infection) Required at an early stage of both clathrin-mediated and clathrin-independent endocytic uptake of a diverse set of viruses, including dengue, West Nile, Sindbis, Rift Valley Fever, influenza, and human rhinoviruses (PubMed:26056282, PubMed:26212330)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Endomembrane system. Cytoplasmic vesicle, clathrin-coated vesicle membrane
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