Protein Name:
Exportin-1
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UniprotKB/SwissProt ID: Q6P5F9 (Q6P5F9)
Gene Name:
Xpo1
Organism: Mus musculus (Mouse)
Function: Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase Ran in its active GTP-bound form. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Nucleus, nucleoplasm. Nucleus, Cajal body. Nucleus, nucleolus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q6P5F9
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
164 |
VGASRTSESL C QNNMVILKLL |
CCCHHHHHHH H HHHHHHCHHH |
5.91% |
24926564
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| 2 |
528 |
VTVIKDLLGL C EQKRGKDNKA |
CCCHHHHHHH H HHHHHHCHHH |
5.03% |
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