Protein Name:
Transportin-3
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UniprotKB/SwissProt ID: Q6P2B1 (Q6P2B1)
Gene Name:
Tnpo3
Organism: Mus musculus (Mouse)
Function: Importin, which transports target proteins into the nucleus. Specifically mediates the nuclear import of splicing factor serine/arginine (SR) proteins, such as RBM4, SFRS1 and SFRS2, by recognizing phosphorylated SR domains. Also mediates the nuclear import of serine/arginine (SR) protein CPSF6, independently of CPSF6 phosphorylation. The nuclear import process is regulated by the small GTPase Ran that partitions between cytoplasm and nucleus in the predominantly GDP- and GTP-bound form, respectively. Importin associates with target cargo proteins in the cytoplasm, and the competitive binding of GTP-bound Ran induces the release of cargos in the nucleus
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus envelope. Cytoplasm
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q6P2B1
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
125 |
LALQMPSWKG C VQTLVEKYSN |
CCCCCCHHHH H HHHHHHHHCC |
1.49% |
20925432
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