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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like

UniprotKB/SwissProt ID: Q6P1R4 (Q6P1R4)

Gene Name: DUS1L

Organism: Homo sapiens (Human)

Function: Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (PubMed:34798057, PubMed:39354220). Specifically modifies U16 and U17 in cytoplasmic tRNAs (PubMed:39354220). Affects the level of some mature tRNA and thereby the total cellular translation (PubMed:39354220)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Nucleus

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR013785 Aldolase_TIM
IPR035587 DUS-like_FMN-bd
IPR018517 tRNA_hU_synthase_CS

The S-nitrosylation sites of Q6P1R4

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 169 RYAQMLEKAG C QLLTVHGRTK   
2 265 EYLDIVREHP C PLSYVRAHLF   
3 406 DQCGNPKGNR C VFSLCRGCCK