UniprotKB/SwissProt ID: Q6P1J1 (Q6P1J1)
Gene Name:
Crmp1
Organism: Mus musculus (Mouse)
Function: Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance. During the axon guidance process, acts downstream of SEMA3A to promote FLNA dissociation from F-actin which results in the rearrangement of the actin cytoskeleton and the collapse of the growth cone. Involved in invasive growth and cell migration. May participate in cytokinesis
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell projection, growth cone. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Perikaryon
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