Protein Name:
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
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UniprotKB/SwissProt ID: Q6P1F6 (Q6P1F6)
Gene Name:
Ppp2r2a
Organism: Mus musculus (Mouse)
Function: Substrate-recognition subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit (PubMed:39003739). Involved in chromosome clustering during late mitosis by mediating dephosphorylation of MKI67 (PubMed:39003739). Essential for serine/threonine-protein phosphatase 2A-mediated dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization:
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Graphical Visualization of S-nitrosylation Sites:
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