Protein Name:
Zinc finger CCHC domain-containing protein 8
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UniprotKB/SwissProt ID: Q6NZY4 (Q6NZY4)
Gene Name:
ZCCHC8
Organism: Homo sapiens (Human)
Function: Scaffolding subunit of the trimeric nuclear exosome targeting (NEXT) complex that is involved in the surveillance and turnover of aberrant transcripts and non-coding RNAs (PubMed:27871484). NEXT functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. May be involved in pre-mRNA splicing (Probable). It is required for 3'-end maturation of telomerase RNA component (TERC), TERC 3'-end targeting to the nuclear RNA exosome, and for telomerase function (PubMed:31488579)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus, nucleoplasm. Nucleus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q6NZY4
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
157 |
LEEDHKVEES C AIKNNKEAFS |
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| 2 |
262 |
SEKRKEYMDA C GEANNQNFQQ |
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| 3 |
56 |
DAELRERLRQ C EETIEQLRAE |
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