UniprotKB/SwissProt ID: Q6NVE9 (Q6NVE9)
Gene Name:
Pptc7
Organism: Mus musculus (Mouse)
Function: Protein phosphatase that plays an essential role in mitochondrial metabolism and biogenesis (PubMed:31324765). Positively regulates biosynthesis of the ubiquinone, coenzyme Q. Dephosphorylates the ubiquinone biosynthesis protein COQ7 which is likely to lead to its activation (By similarity). Serves as a crucial sensor for mitophagy, though the underlying mechanism remains ambiguous (PubMed:37833277, PubMed:38151018). May dephosphorylate BNIP3 and NIX and thereby directly regulates mitophagy receptor function and stability (PubMed:37833277). Alternatively, promotes SCF-FBXL4-dependent ubiquitination and degradation of BNIP3 and NIX independently of its catalytic activity to restrain mitophagy (PubMed:38151018)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion matrix
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