UniprotKB/SwissProt ID: Q6NUT7 (Q6NUT7)
Gene Name:
sort1
Organism: Danio rerio (Zebrafish)
Function: Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Lysosomal proteins bind specifically to the receptor in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex. The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer. Also required for protein transport from the Golgi apparatus to the endosomes. May also mediate transport from the endoplasmic reticulum to the Golgi
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Golgi apparatus, Golgi stack membrane. Endosome membrane. Endoplasmic reticulum membrane. Nucleus membrane. Cell membrane. Lysosome membrane
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