Protein Name:
Nipped-B-like protein
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UniprotKB/SwissProt ID: Q6KC79 (Q6KC79)
Gene Name:
NIPBL
Organism: Homo sapiens (Human)
Function: Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Chromosome
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q6KC79
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
1066 |
LAEIESTMPL C ERVKMNKRKR |
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| 2 |
1754 |
NSDTVDYDDA C LIVRYLASMR |
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| 3 |
1795 |
AIAVRTKAMK C LSEVVAVDPS |
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| 4 |
1940 |
ILNITDVVAA C RDTGYDWFEQ |
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| 5 |
279 |
SFPLRSPQPV C SPAGSEGTPK |
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| 6 |
304 |
PLILQSQSLP C SSPRDVPPDI |
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| 7 |
573 |
SIKKPEEIKQ C NDAPVSVLQE |
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| 8 |
661 |
LKQNESRTTE C KQNESTIVEP |
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