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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Astacin-like metalloendopeptidase

UniprotKB/SwissProt ID: Q6HA09 (Q6HA09)

Gene Name: Astl

Organism: Mus musculus (Mouse)

Function: Oocyte-specific oolemmal receptor involved in sperm and egg adhesion and fertilization. Plays a role in the polyspermy inhibition. Probably acts as a protease for the post-fertilization cleavage of ZP2. Cleaves the sperm-binding ZP2 at the surface of the zona pellucida after fertilization and cortical granule exocytosis, rendering the zona pellucida unable to support further sperm binding

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Cell membrane. Cytoplasmic vesicle, secretory vesicle, Cortical granule

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR024079 MetalloPept_cat_dom_sf
IPR001506 Peptidase_M12A
IPR006026 Peptidase_Metallo

The S-nitrosylation sites of Q6HA09

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 172 GMQVVSLAPT C LRKGRGIVLH