UniprotKB/SwissProt ID: Q69ZS7 (Q69ZS7)
Gene Name:
Hbs1l
Organism: Mus musculus (Mouse)
Function: GTPase component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway. The Pelota-HBS1L complex recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel. Following mRNA extraction from stalled ribosomes by the SKI complex, the Pelota-HBS1L complex promotes recruitment of ABCE1, which drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm
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