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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

UniprotKB/SwissProt ID: Q69ZK0 (Q69ZK0)

Gene Name: Prex1

Organism: Mus musculus (Mouse)

Function: Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils (By similarity)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm, cytosol. Cell membrane

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR035899 DBL_dom_sf
IPR000591 DEP_dom
IPR000219 DH_dom
IPR001331 GDS_CDC24_CS
IPR051832 mTOR-Rac_regulators
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR055251 SOS1_NGEF_PH
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf

The S-nitrosylation sites of Q69ZK0

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 32 PDARGPVSGP C AAARDSERQL   
2 741 RGSEAVAAGL C AGQCILKVNG