\
logo
  Home | Contact us | Browse | Quick Search by UniProtKB ID, Keyword, PDBID

Menu:

Latest news:

Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

Read more...


Protein Name: Clathrin heavy chain 1
UniprotKB/SwissProt ID: Q68FD5 (Q68FD5)

Gene Name: Cltc

Organism: Mus musculus (Mouse)

Function: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension. Plays a role in early autophagosome formation. Interaction with DNAJC6 mediates the recruitment of HSPA8 to the clathrin lattice and creates local destabilization of the lattice promoting uncoating (By similarity)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasmic vesicle membrane. Membrane, coated pit. Melanosome. Cytoplasm, cytoskeleton, spindle

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR016024 ARM-type_fold
IPR055358 CHCR
IPR000547 Clathrin_H-chain/VPS_repeat
IPR015348 Clathrin_H-chain_linker_core
IPR016025 Clathrin_H-chain_N
IPR022365 Clathrin_H-chain_propeller_rpt
IPR016341 Clathrin_heavy_chain
IPR011990 TPR-like_helical_dom_sf
The S-nitrosylation sites of Q68FD5
No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 1102 LDRAYEFAER C NEPAVWSQLA  CCCCCCCCHH H HHHHHCCCCC  24895380
20925432
2 1205 NAHIQQVGDR C YDEKMYDAAK  CCCCCCCCHH H HHHHHCCCCC 
3 1257 ANSTRTWKEV C FACVDGKEFR  CCCCCCCCHH H HHHHHCCCCC 
4 151 MFDRHSSLAG C QIINYRTDAK  CCCCCCCCHH H HHHHHCCCCC  24895380
22588120
20925432
5 459 EKWLKEDKLE C SEELGDLVKS  CCCCCCCCHH H HHHHHCCCCC  20925432
6 491 RANVPNKVIQ C FAETGQVQKI  CCCCCCCCHH H HHHHHCCCCC  24895380
22588120
20925432
21278135
7 617 HYDRAHIAQL C EKAGLLQRAL  CCCCCCCCHH H HHHHHCCCCC 
8 736 DVHFKYIQAA C KTGQIKEVER  CCCCCCCCHH H HHHHHCCCCC 
9 824 VVIGGLLDVD C SEDVIKNLIL  CCCCCCCCHH H HHHHHCCCCC 
10 870 PWLEARIHEG C EEPATHNALA  CCCCCCCCHH H HHHHHCCCCC 
11 909 YYDSRVVGKY C EKRDPHLACV  CCCCCCCCHH H HHHHHCCCCC 
12 918 YCEKRDPHLA C VAYERGQCDL  CCCCCCCCHH H HHHHHCCCCC  20925432
21278135
13 926 LACVAYERGQ C DLELINVCNE  CCCCCCCCHH H HHHHHCCCCC  24895380
22588120
20925432
14 934 GQCDLELINV C NENSLFKSLS  CCCCCCCCHH H HHHHHCCCCC  22588120