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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Schlafen family member 13

UniprotKB/SwissProt ID: Q68D06 (Q68D06)

Gene Name: SLFN13

Organism: Homo sapiens (Human)

Function: Endoribonuclease that cleaves tRNAs and rRNAs (PubMed:29563550). Cleaves tRNAs 11 nucleotides from the 3'-terminus at the acceptor stem (PubMed:29563550). Does not act on tRNA(Sec) (PubMed:29563550). Able to restrict HIV-1 virus replication; ability to inhibit HIV-1 replication is dependent on endoribonuclease activity (PubMed:29563550)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR027417 P-loop_NTPase
IPR031450 Poxin-SLFN/SLFN_N
IPR029684 Schlafen
IPR007421 Schlafen_AlbA_2_dom
IPR038461 Schlafen_AlbA_2_dom_sf
IPR018647 SLFN_3-like_DNA/RNA_helicase
IPR048729 SLFN_GTPase-like

The S-nitrosylation sites of Q68D06

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 631 HCEAHRILYV C ENQPLRNFIS