Protein Name:
Metalloreductase STEAP4
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UniprotKB/SwissProt ID: Q687X5 (Q687X5)
Gene Name:
STEAP4
Organism: Homo sapiens (Human)
Function: Integral membrane protein that functions as a NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane. Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe(3+) chelate (PubMed:30337524). Can also reduce Cu(2+) to Cu(1+) (By similarity). Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (By similarity). Associated with obesity and insulin-resistance (PubMed:18381574, PubMed:18430367). Involved in inflammatory arthritis, through the regulation of inflammatory cytokines (PubMed:19660107). Inhibits anchorage-independent cell proliferation (PubMed:19787193)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Golgi apparatus membrane. Early endosome membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q687X5
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
156 |
ALDASRQVFV C GNDSKAKQRV |
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| 2 |
5 |
------MEKT C IDALPLTMNS |
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