Protein Name:
Heat shock protein 105 kDa
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UniprotKB/SwissProt ID: Q66HA8 (Q66HA8)
Gene Name:
Hsph1
Organism: Rattus norvegicus (Rat)
Function: Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering substrate release. Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q66HA8
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
34 |
ETIANEFSDR C TPSVISFGPK |
CCEEEEECCC C EEEEEHHHCC |
8.67% |
22178444
19101475
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| 2 |
659 |
KLCGPYEKFI C EQEHEKFLRL |
CCEEEEECCC C EEEEEHHHCC |
5.06% |
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