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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Tripeptidyl-peptidase 2

UniprotKB/SwissProt ID: Q64560 (Q64560)

Gene Name: Tpp2

Organism: Rattus norvegicus (Rat)

Function: Cytosolic tripeptidyl-peptidase that releases N-terminal tripeptides from polypeptides and is a component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. It plays an important role in intracellular amino acid homeostasis (By similarity). Stimulates adipogenesis (By similarity)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Nucleus

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR000209 Peptidase_S8/S53_dom
IPR036852 Peptidase_S8/S53_dom_sf
IPR022398 Peptidase_S8_His-AS
IPR023828 Peptidase_S8_Ser-AS
IPR050131 Peptidase_S8_subtilisin-like
IPR015500 Peptidase_S8_subtilisin-rel
IPR034051 TPP_II_domain
IPR022232 TPPII_C_art
IPR046939 TPPII_C_sf
IPR048384 TPPII_GBD
IPR048383 TPPII_Ig-like-1
IPR022229 TPPII_Ig-like-2
IPR046940 TPPII_Ig-like_sf

The S-nitrosylation sites of Q64560

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 209 VWHDGETWRA C VDSNENGDLG   
2 28 KKETGASSFL C RYPEYDGRGV   
3 342 ATHWPNSGRI C EVINEAVWKH   
4 787 SSLKYEDLAP C ITLKSWVQTL   
5 967 DKIPKGAGPG C YLAGSLTLSK