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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Tripeptidyl-peptidase 2
UniprotKB/SwissProt ID: Q64514 (Q64514)

Gene Name: Tpp2

Organism: Mus musculus (Mouse)

Function: Cytosolic tripeptidyl-peptidase that releases N-terminal tripeptides from polypeptides and is a component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. It plays an important role in intracellular amino acid homeostasis (By similarity). Stimulates adipogenesis (PubMed:17932511)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Nucleus

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR000209 Peptidase_S8/S53_dom
IPR036852 Peptidase_S8/S53_dom_sf
IPR022398 Peptidase_S8_His-AS
IPR023828 Peptidase_S8_Ser-AS
IPR050131 Peptidase_S8_subtilisin-like
IPR015500 Peptidase_S8_subtilisin-rel
IPR034051 TPP_II_domain
IPR022232 TPPII_C_art
IPR046939 TPPII_C_sf
IPR048384 TPPII_GBD
IPR048383 TPPII_Ig-like-1
IPR022229 TPPII_Ig-like-2
IPR046940 TPPII_Ig-like_sf
The S-nitrosylation sites of Q64514
No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 1231 EKPTKENWKN C IQLMKLLGWT  CCCCCCCCCC C CCCCCCCCCC  1.54%
2 150 PIHRVALAEA C RKQEEFDIAN  CCCCCCCCCC C CCCCCCCCCC  4.15% 20925432
3 209 VWHDGETWRA C VDSNENGDLS  CCCCCCCCCC C CCCCCCCCCC  2.34% 21278135
4 614 LREGLHYTEV C GYDIASPNAG  CCCCCCCCCC C CCCCCCCCCC  3.21% 20925432
5 967 DKIPKGAGPG C YLAGSLTLSK  CCCCCCCCCC C CCCCCCCCCC  2.57%